Research Scientist, Platform Technology

Job title:

Research Scientist, Platform Technology

Company

Bicycle Therapeutics

Job description

Company DescriptionBicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts US.Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination
• We are One Team. We only succeed when we work together.

Job DescriptionWe have an exciting new opportunity for a skilled and diligent Research Scientist to join our dynamic Platform Technology and Science team.You will enjoy a varied and rewarding role working in a multi-disciplinary environment to develop and deploy our proprietary technology. The role will involve providing essential support to Bicycle’s early drug discovery efforts by identifying Bicycle binders to targets of interest using our unique phage display platform. The role will also involve significant cross-functional collaboration to deliver technology and process improvements.you will be a highly motivated, methodical, well-organised individual who enjoys working at the bench. Previous experience in a multi-disciplinary lab utilizing molecular biology, biochemical and biophysical techniques is essential. Experience of working with phage or other display technologies is not required. The role would suit someone looking for a high degree of hands-on practical work where their efforts can impact broadly.This opportunity allows meaningful contribution to our efforts in finding new life-changing drugs.Key responsibilities

• Plan, execute and troubleshoot phage display campaigns using proprietary Bicycle platform

• Phage panning, library design, sequencing (Sanger & NGS)
• Characterise Bicycle binders identified, e.g. AlphaScreen/ELISA, SPR, flow cytometry
• Interpret structure activity relationships to inform chemical optimisation
• Design, test and implement innovations to platform technology

• Stay up to date with current literature in the area, seek ideas from internal and external sources to bring about process/technology evolution
• Facilitate adoption through stakeholder engagement and rigorous validation
• Generate robust data packages to support project milestones
• Accurate and timely record keeping via electronic lab notebook system (Dotmatics)
• Analyse and present complex data to internal and external stakeholders
• Willing to take on additional responsibilities outside of core role such as EH&S roles, being “super user” for lab equipment etc.

QualificationsEssential:

• A PhD in a biological or chemical subject, or equivalent scientific grounding
• Experience of working in a multi-disciplinary, industrial laboratory
• Detailed understanding of protein biochemistry
• Theoretical knowledge and practical experience of biophysical techniques
• Demonstrable track record problem solving and improving laboratory processes
• Ability to plan, conduct and critically analyse experimental work
• Diligence in documenting work and understanding of the importance of data integrity
• Proactive approach to problem solving and strong self-motivation
• Excellent organisational skills, effective at managing time between lab bench and office
• Close attention to detail, willingness to seek peer review and provide critical analysis
• Strong interpersonal skills; effective communication with multidisciplinary teams both locally and remotely

Desirable:

• Phage or other display technology experience
• High throughput screening of biologics, peptides or small molecules
• Degree level chemistry or biochemistry

Additional Information

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute)
• Life assurance cover 4x basic salary
• Private Medical Insurance, including optical and dental cover.
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership.
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

Expected salary

Location

Cambridge

Job date

Sat, 12 Oct 2024 22:59:26 GMT

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