GlaxoSmithKline
Job title:
Senior Scientist – Antibody Engineering
Company
GlaxoSmithKline
Job description
The Large Molecule Discovery (LMD) department within GSK is dedicated to the discovery of innovative biopharmaceutical medicines. This department encompasses several complementary functions that focus on the progression of a portfolio of biopharmaceuticals, from initial antibody discovery, expression, and characterization to molecular engineering, biological, and physicochemical profiling. Within LMD, the Molecular Design and Engineering (MDE) group is responsible for antibody engineering and developability profiling before candidate selection, with the aim of continuously improving molecule quality and transforming discovered leads into therapeutics.We are currently in search of a diligent and motivated scientist to join the Antibody Engineering team within MDE. The role will be equally divided between lab work and computational/data analysis. The responsibilities will include working with matrix program teams, identifying risks and liabilities to early-stage biologics using predictive models and sequence analysis, designing de-risked and more developable variants, and executing molecular biology work packages (such as cloning, DNA upscaling) to generate plasmids for expression. These activities will primarily focus on the delivery of more developable molecule variants. We are constantly evolving by implementing cutting-edge data and automation technologies. The new team member will strengthen computational capabilities of the team and will contribute to the development and deployment of new models for predicting antibody properties and designing more developable variants.Key responsibilities:Analysing antibody sequences & structures. Interpreting data from predictive models to identify potential liabilities and to design de-risked variants.Providing strategic recommendations for molecule engineering, humanization, and de-risking to program teams.Developing and exploring innovative engineering strategies with the aim of creating evolutionarily plausible variants with strong developability profiles.Cloning antibodies, bispecifics, and other advanced formats into expression vectors, followed by sequencing and upscaling the generated plasmids.Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:Graduate or postgraduate degree in Molecular Biology, Biochemistry, Biotechnology, or a related discipline.A strong interest and experience in applying AI to protein sequence, structure, and experimental data, particularly in the context of drug/biologic design and engineering.Experience in protein/antibody modelling and interpretation of the structure data. Experience in developing scripts and applications to automate data analysis to support drug discoveryBasic skills in molecular biology, protein design and engineering, DNA cloning, preparation, upscaling, and analysis of sequencing results.Ability to quickly adapt to new scientific areas and work collaboratively across teams.Preferred Qualifications & Skills:If you have the following characteristics, it would be a plus:Established experience in antibody discovery and/or design, with a broad scientific understanding of the relationship between antibody sequence/structure and function.Basic experience or knowledge about bispecifics and other advanced antibody formats.Closing Date for Applications: 16th October 2024Please take a copy of the Job Description, as this will not be available post closure of the advert.When applying for this role, please use your CV to describe how you meet the competencies for this role, or you can include a ‘cover letter’ in the online application as well, as outlined in the job requirements.The information that you have provided in your cover letter and CV will be used to assess your application.Thank you for your interest in this opportunity!Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391.Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the and scroll to the Careers Section where you will find answers to multiple questions we receiveAs you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting site.
Expected salary
Location
Stevenage, Hertfordshire
Job date
Wed, 18 Sep 2024 07:46:51 GMT
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